I'm diagnosed with severe depression (ICD has categories, don't know how it's handled with DSM, also dx'd with OCD and GAD) and honestly I'm on 2 different meds (about to start a 3rd one tomorrow) and I still can't do shit! No motivation to do anything! But today I plan on going out for the first time in a month and I'm so scared.
The worst time however was when I had psychotic symptoms - paranoia that all my (two) friends and family hate me and secretly conspire behind my back to hurt me - and I'm just glad this stopped. I still get these thoughts sometimes but I can distance myself from them now and recognize them as being irrational (yay no conspiracy).